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Article

Mutations in conserved regions 1, 2, and 3 of Raf-1 that activate transforming activity.

Molecular carcinogenesis - 1 Apr 2002

Chan Edmond Y W, Stang Stacey L, Bottorff Drell A, Stone James C

Abstract excerpt

To investigate the role of Raf-1 in v-Ha-ras transformation, we have isolated and characterized a number of Raf-1 mutants that display increased transforming activity in Rat2 fibroblasts. A dipeptide deletion (Delta144-145) in the cysteine-rich domain (CRD) of conserved region (CR) 1 increased the interaction between Raf-1 and v-Ha-ras effector loop mutants in the yeast two-hybrid system, supporting the proposal...

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Share to Conserved Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Genes, ras

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Share to Mitogen-Activated Protein Kinases

Share to Proto-Oncogene Proteins c-raf

Source

Identifiers

PMID: 11933072
DOI: 10.1002/mc.10031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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