A mutation in the effector region of Ras2 can be partially suppressed by alteration of a 'nonessential' region of Ras.

doi:10.1016/0378-1119(94)90047-7

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Article

A mutation in the effector region of Ras2 can be partially suppressed by alteration of a 'nonessential' region of Ras.

Gene - 15 Sept 1994

Chen L, Powers S

Abstract excerpt

Phenotypically normal revertants of budding yeast cells that contain the hyperactive RAS2Val19 allele often result from second-site mutations within the RAS2 locus itself. Several such intragenic revertants harboring a suppressed RAS2Val19 allele as their only RAS gene were analyzed. All such suppressors resulted from single amino acid substitutions that affected either: (i) the effector region of Ras2, (ii) the...

Topics

Base Sequence
DNA Primers
Fungal Proteins
GTP-Binding Proteins
Genes, Fungal
Genes, Suppressor
Genes, ras
Guanine Nucleotides
Molecular Sequence Data
Mutation
Protein Processing, Post-Translational

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins p21(ras)

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Structure-Activity Relationship

Valine

ras Proteins

Source

Open in PubMed

Identifiers

PMID: 8088533
DOI: 10.1016/0378-1119(94)90047-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8088533-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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