Article
A mutation in the effector region of Ras2 can be partially suppressed by alteration of a 'nonessential' region of Ras.
Gene - 15 Sept 1994
Chen L, Powers S
Abstract excerpt
Phenotypically normal revertants of budding yeast cells that contain the hyperactive RAS2Val19 allele often result from second-site mutations within the RAS2 locus itself. Several such intragenic revertants harboring a suppressed RAS2Val19 allele as their only RAS gene were analyzed. All such suppressors resulted from single amino acid substitutions that affected either: (i) the effector region of Ras2, (ii) the...
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