Article
Identification of a novel RalGDS-related protein as a candidate effector for Ras and Rap1.
The Journal of biological chemistry - 22 Nov 1996
Peterson S N, Trabalzini L, Brtva T R, Fischer T, Altschuler D L, Martelli P, Lapetina E G, Der C J, White G C
Abstract excerpt
Although Ras and Rap1 share interaction with common candidate effector proteins, Rap1 lacks the transforming activity exhibited by Ras proteins. It has been speculated that Rap antagonizes Ras transformation through the formation of nonproductive complexes with critical Ras effector targets. To understand further the distinct biological functions of these two closely related proteins, we searched for...
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