Article
The P34G mutation reduces the transforming activity of K-Ras and N-Ras in NIH 3T3 cells but not of H-Ras.
The Journal of biological chemistry - 6 Aug 2004
Oliva José Luis, Zarich Natasha, Martínez Natalia, Jorge Rocío, Castrillo Antonio, Azañedo Marta, García-Vargas Susana, Gutiérrez-Eisman Silvia, Juarranz Angeles, Boscá Lisardo, Gutkind J Silvio, Rojas José M
Abstract excerpt
Ras proteins (H-, N-, and K-Ras) operate as molecular switches in signal transduction cascades controlling cell proliferation, differentiation, or apoptosis. The interaction of Ras with its effectors is mediated by the effector-binding loop, but different data about Ras location to plasma membrane subdomains and new roles for some docking/scaffold proteins point to signaling specificities of the different Ras...
Topics
- Animals
- Binding Sites
- DNA-Binding Proteins
- Enzyme Activation
- Gene Expression
- Genes, ras
- Humans
- Mice
- Mitogen-Activated Protein Kinase 1
- Mitogen-Activated Protein Kinase 3