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Article

Multiple Ras functions can contribute to mammalian cell transformation.

Cell - 24 Feb 1995

White M A, Nicolette C, Minden A, Polverino A, Van Aelst L, Karin M, Wigler M H

Abstract excerpt

We have developed a generalized approach, using two hybrid interactions, to isolate Ha-Ras effector loop mutations that separate the ability of Ha-Ras to interact with different downstream effectors. These mutations attenuate or eliminate Ha-ras(G12V) transformation of mammalian cells, but retain complementary activity, as demonstrated by synergistic induction of foci of growth-transformed cells, and by the...

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PMID: 7867061
DOI: 10.1016/0092-8674(95)90507-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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