Article
Genetic definition of ras effector elements.
Molecular and cellular biology - 1 Dec 1991
Stone J C, Blanchard R A
Abstract excerpt
The products of ras genes may function as GTP-binding signal transducers, but the nature of their targets is largely unknown. To define genetically the cellular effector(s) of ras in rat fibroblast transformation, somatic variants that suppress the nontransforming phenotype of v-H-ras effector domain mutations were sought. Variant cell lines perturbed in the ras effector pathway were recovered, and the properties...
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