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Article

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1.

Nature - 22 Jul 1993

Zhang X F, Settleman J, Kyriakis J M, Takeuchi-Suzuki E, Elledge S J, Marshall M S, Bruder J T, Rapp U R, Avruch J

Abstract excerpt

In higher eukaryotes, the Ras and Raf-1 proto-oncoproteins transduce growth and differentiation signals initiated by tyrosine kinases. The Ras polypeptide and the amino-terminal regulatory domain of Raf-1 (residues 1-257) are shown to interact, directly in vitro and in a yeast expression system. Raf-1 (1-257) binds GTP-Ras in preference to GDP-Ras, and inhibits Ras-GAP activity. Mutations in and around the Ras...

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PMID: 8332187
DOI: 10.1038/364308a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1.PMID 8332187Read ↗

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Direct link between RACK1 function and localization at the ribosome in vivo.Semantic proximity Read ↗

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