R-Ras is regulated by activators and effectors distinct from those that control Ras function.

doi:10.1038/sj.onc.1200815

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Article

R-Ras is regulated by activators and effectors distinct from those that control Ras function.

Oncogene - 16 Jan 1997

Huff S Y, Quilliam L A, Cox A D, Der C J

Abstract excerpt

Like Ras, constitutively activated mutants of the Ras-related protein R-Ras cause tumorigenic transformation of NIH3T3 cells. However, since R-Ras causes a transformed phenotype distinct from that induced by Ras, it is likely that R-Ras controls signaling pathways and cellular processes distinct...

Topics

3T3 Cells
Animals
Cell Division
Cell Transformation, Neoplastic
GTP Phosphohydrolases
GTP-Binding Proteins
Guanosine Diphosphate
Guanosine Triphosphate
Mice
Mutation
Protein Serine-Threonine Kinases
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-raf
rap GTP-Binding Proteins
ras Proteins

Source

Open in PubMed

Identifiers

PMID: 9010215
DOI: 10.1038/sj.onc.1200815

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9010215-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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