Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

R-Ras is regulated by activators and effectors distinct from those that control Ras function.

Oncogene - 16 Jan 1997

Huff S Y, Quilliam L A, Cox A D, Der C J

Abstract excerpt

Like Ras, constitutively activated mutants of the Ras-related protein R-Ras cause tumorigenic transformation of NIH3T3 cells. However, since R-Ras causes a transformed phenotype distinct from that induced by Ras, it is likely that R-Ras controls signaling pathways and cellular processes distinct from those regulated by Ras. To address this possibility, we determined if R-Ras is regulated by activators and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3 Cells
Share to Cell Division
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to GTP-Binding Proteins

Share to Mutation

Share to Protein Serine-Threonine Kinases

Share to Proto-Oncogene Proteins

Source

Identifiers

PMID: 9010215
DOI: 10.1038/sj.onc.1200815

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

R-Ras is regulated by activators and effectors distinct from those that control Ras function.PMID 9010215Read ↗

Genetic and pharmacologic dissection of Ras effector utilization in oncogenesis.Semantic proximity Read ↗

The dominant negative Ras mutant, N17Ras, can inhibit signaling independently of blocking Ras activation.Semantic proximity Read ↗

Distinct utilization of effectors and biological outcomes resulting from site-specific Ras activation: Ras functions in lipid rafts and Golgi complex are dispensable for proliferation and transformation.Semantic proximity Read ↗

Many faces of Ras activation.Semantic proximity Read ↗

A perspective on the early days of RAS researchSemantic proximity Read ↗

Differential roles of Akt, Rac, and Ral in R-Ras-mediated cellular transformation, adhesion, and survival.Semantic proximity Read ↗

RASSF4/AD037 Is a Potential Ras Effector/Tumor Suppressor of the RASSF FamilySemantic proximity Read ↗

Rho GTPases in transformation and metastasis.Semantic proximity Read ↗

Multiple Ras functions can contribute to mammalian cell transformation.Semantic proximity Read ↗

Interaction of activated Ras with Raf-1 alone may be sufficient for transformation of rat2 cells.Semantic proximity Read ↗

Rit, a non-lipid-modified Ras-related protein, transforms NIH3T3 cells without activating the ERK, JNK, p38 MAPK or PI3K/Akt pathways.Semantic proximity Read ↗

Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.