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Article

Conditional, tissue-specific expression of Q205L G alpha i2 in vivo mimics insulin action.

Journal of molecular medicine (Berlin, Germany) - 1 Apr 1997

Chen J F, Guo J H, Moxham C M, Wang H Y, Malbon C C

Abstract excerpt

Deficiency of the G protein subunit G alpha i2 that is known to mediate the inhibitory control of adenylylcyclase impairs insulin action [11]. Using the promoter for the phosphoenolpyruvate carboxykinase gene, conditional tissue-specific expression of the constitutively active mutant form (Q205L) of G alpha i2 was achieved in mice harboring the transgene. Expression of Q205L G alpha i2 was detected in liver and...

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PMID: 9151214
DOI: 10.1007/s001090050113

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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