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Article

G6PC2 confers protection against hypoglycemia upon ketogenic diet feeding and prolonged fasting.

Molecular metabolism - 1 Nov 2020

Bosma Karin J, Rahim Mohsin, Oeser James K, McGuinness Owen P, Young Jamey D, O'Brien Richard M

Abstract excerpt

OBJECTIVE: G6PC2 is predominantly expressed in pancreatic islet beta cells. G6PC2 hydrolyzes glucose-6-phosphate to glucose and inorganic phosphate, thereby creating a futile substrate cycle that opposes the action of glucokinase. This substrate cycle determines the sensitivity of glucose-stimulated insulin secretion to glucose and hence regulates fasting blood glucose (FBG) but not fasting plasma insulin (FPI)...

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Source

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Identifiers

PMID: 32569842
DOI: 10.1016/j.molmet.2020.101043
PMCID: PMC7369601

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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