Article
Transgenic knockouts reveal a critical requirement for pancreatic beta cell glucokinase in maintaining glucose homeostasis.
Cell - 6 Oct 1995
Grupe A, Hultgren B, Ryan A, Ma Y H, Bauer M, Stewart T A
Abstract excerpt
The secretion of insulin is controlled by the rate of glucose metabolism in the pancreatic beta cells. As phosphorylation by glucokinase (GLK) appears to be the rate-limiting step for glucose catabolism in beta cells, this enzyme may be the glucose sensor. To test this possibility and to resolve the relative roles of liver and beta cell GLK in maintaining glucose levels, we have generated mice completely...
Topics
- Alleles
- Animals
- Blood Glucose
- Diabetes Mellitus, Type 2
- Disease Models, Animal
- Enzyme Induction
- Female
- Genes, Lethal
- Glucokinase
- Glucose
- Homeostasis
- Hyperglycemia