Article
Expression of a dominant-negative mutant human insulin receptor in the muscle of transgenic mice.
The Journal of biological chemistry - 10 Jun 1994
Chang P Y, Benecke H, Le Marchand-Brustel Y, Lawitts J, Moller D E
Abstract excerpt
To examine the in vivo effects of a kinase-deficient mutant human insulin receptor, we used the muscle creatine kinase promoter to express a putative dominant-negative receptor: Ala1134-->Thr (Moller, D. E., Yokota, A., White, M. F., Pazianos, A. G., and Flier, J. S. (1990) J. Biol. Chem. 265, 14979-14985) in transgenic mice. Two lines were generated, where receptor expression was restricted to striated muscle...
Topics
- Animals
- Base Sequence
- Buttocks
- Deoxyglucose
- Glucose
- Glucose Tolerance Test
- Glycogen
- Humans
- Insulin
- Mice
- Mice, Transgenic
- Molecular Sequence Data