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Article

Functional characterization of naturally occurring transglutaminase 2 mutants implicated in early-onset type 2 diabetes.

Journal of molecular endocrinology - 1 Jun 2012

Salter Neil W, Ande Sudharsana R, Nguyen Hoa K, Nyomba B L Grégoire, Mishra Suresh

Abstract excerpt

Transglutaminase 2 (TG2) is an enzyme with diverse biological functions. TG2 catalyzes transamidation reactions, has intrinsic kinase activity, and acts as a G-protein in intracellular signaling. TG2 (Tgm2)-null mice are glucose intolerant and have impaired glucose-stimulated insulin secretion (G...

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Source

Identifiers

PMID: 22394545
DOI: 10.1530/JME-11-0064

Genes

INS
TGM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22394545-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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