Article
Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase.
The Journal of biological chemistry - 1 Jan 1999
Postic C, Shiota M, Niswender K D, Jetton T L, Chen Y, Moates J M, Shelton K D, Lindner J, Cherrington A D, Magnuson M A
Abstract excerpt
Glucokinase (GK) gene mutations cause diabetes mellitus in both humans and mouse models, but the pathophysiological basis is only partially defined. We have used cre-loxP technology in combination with gene targeting to perform global, beta cell-, and hepatocyte-specific gene knock-outs of this enzyme in mice. Gene targeting was used to create a triple-loxed gk allele, which was converted by partial or total...
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