Article
Glucokinase gene locus transgenic mice are resistant to the development of obesity-induced type 2 diabetes.
Diabetes - 1 Mar 2001
Shiota M, Postic C, Fujimoto Y, Jetton T L, Dixon K, Pan D, Grimsby J, Grippo J F, Magnuson M A, Cherrington A D
Abstract excerpt
Transgenic mice that overexpress the entire glucokinase (GK) gene locus have been previously shown to be mildly hypoglycemic and to have improved tolerance to glucose. To determine whether increased GK might also prevent or diminish diabetes in diet-induced obese animals, we examined the effect of feeding these mice a high-fat high-simple carbohydrate low-fiber diet (HF diet) for 30 weeks. In response to this...
Topics
- Animals
- Blood Glucose
- Chromosome Mapping
- Diabetes Mellitus, Type 2
- Dietary Fats
- Genetic Predisposition to Disease
- Glucagon
- Glucokinase
- Insulin
- Liver
- Mice
- Mice, Transgenic
- Obesity
- RNA, Messenger