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Article

Characterization of a mutation in the parE gene that confers fluoroquinolone resistance in Streptococcus pneumoniae.

Antimicrobial agents and chemotherapy - 1 May 1997

Perichon B, Tankovic J, Courvalin P

Abstract excerpt

We report a mutation in the parE genes of two in vitro mutants of Streptococcus pneumoniae responsible for low-level resistance to fluoroquinolones. Sequential acquisition of mutations in parE and gyrA leads to higher levels of resistance. This confirms that topoisomerase IV is the primary target of fluoroquinolones in S. pneumoniae.

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 9145891
DOI: 10.1128/AAC.41.5.1166
PMCID: PMC163872

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Characterization of a mutation in the parE gene that confers fluoroquinolone resistance in Streptococcus pneumoniae.PMID 9145891Read ↗

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