Characterization of a mutation in the parE gene that confers fluoroquinolone resistance in Streptococcus pneumoniae.

doi:10.1128/AAC.41.5.1166

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Article

Characterization of a mutation in the parE gene that confers fluoroquinolone resistance in Streptococcus pneumoniae.

Antimicrobial agents and chemotherapy - 1 May 1997

Perichon B, Tankovic J, Courvalin P

Abstract excerpt

We report a mutation in the parE genes of two in vitro mutants of Streptococcus pneumoniae responsible for low-level resistance to fluoroquinolones. Sequential acquisition of mutations in parE and gyrA leads to higher levels of resistance. This confirms that topoisomerase IV is the primary target...

Topics

Anti-Infective Agents
Bacterial Proteins
DNA Topoisomerase IV
DNA-Binding Proteins
Drug Resistance, Microbial
Fluoroquinolones
Microbial Sensitivity Tests
Mutation
Streptococcus pneumoniae

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