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Article

Prevalence of Ile-460-Val/ParE substitution in clinical Streptococcus pneumoniae isolates that were less susceptible to fluoroquinolones.

Current microbiology - 1 Jul 2005

Kawamura-Sato Kumiko, Hasegawa Tadao, Torii Keizo, Ito Hideo, Ohta Michio

Abstract excerpt

A total of 73 clinical isolates of Streptococcus pneumoniae were measured for susceptibilities to nine fluoroquinolones, and nucleotide sequences of the quinolone resistance-determining regions (QRDRs) were determined. MIC90s of sparfloxacin, tosufloxacin, grepafloxacin, and gatifloxacin were less than 0.5 mg/L and the MIC90 of ciprofloxacin was 2 mg/L, although MIC values of some isolates to ciprofloxacin were...

Topics

Amino Acid Substitution
DNA Topoisomerase IV
Drug Resistance, Microbial
Fluoroquinolones
Humans
Microbial Sensitivity Tests
Mutation
Prevalence
Streptococcus pneumoniae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15942701
DOI: 10.1007/s00284-005-4439-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-15942701-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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