Article
ParC subunit of DNA topoisomerase IV of Streptococcus pneumoniae is a primary target of fluoroquinolones and cooperates with DNA gyrase A subunit in forming resistance phenotype.
Antimicrobial agents and chemotherapy - 1 Oct 1996
Muñoz R, De La Campa A G
Abstract excerpt
The genes encoding the ParC and ParE subunits of topoisomerase IV of Streptococcus pneumoniae, together with the region encoding amino acids 46 to 172 (residue numbers are as in Escherichia coli) of the pneumococcal GyrA subunit, were partially characterized. The gyrA gene maps to a physical location distant from the gyrB and parC loci on the chromosome, whereas parC is closely linked to parE....
Topics
- Amino Acid Sequence
- Anti-Infective Agents
- Base Sequence
- Chromosomes, Bacterial
- DNA Topoisomerase IV
- DNA Topoisomerases, Type II
- DNA, Bacterial
- Drug Resistance, Microbial
- Electrophoresis, Polyacrylamide Gel
- Fluoroquinolones