Quinolone resistance locus nfxD of Escherichia coli is a mutant allele of the parE gene encoding a subunit of topoisomerase IV.

doi:10.1128/AAC.41.1.175

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Article

Quinolone resistance locus nfxD of Escherichia coli is a mutant allele of the parE gene encoding a subunit of topoisomerase IV.

Antimicrobial agents and chemotherapy - 1 Jan 1997

Breines D M, Ouabdesselam S, Ng E Y, Tankovic J, Shah S, Soussy C J, Hooper D C

Abstract excerpt

The locus nfxD, which contributes to high-level quinolone resistance in Escherichia coli KF111b (gyrAr nfxB nfxD), is only expressed in the presence of a gyrA mutation, and maps to the region of the parC and parE genes, was outcrossed into strain KF130, creating strain DH161 (gyrAr nfxD). DNA seq...

Topics

Alleles
Anti-Infective Agents
Bacterial Proteins
Cloning, Molecular
DNA Topoisomerase IV
DNA Topoisomerases, Type II
DNA-Binding Proteins
Drug Resistance, Microbial
Escherichia coli
Genes, Bacterial
Mutation
Norfloxacin
Plasmids
Temperature

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Identifiers

PMID: 8980775
DOI: 10.1128/AAC.41.1.175
PMCID: PMC163680

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8980775-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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