Article
Selection and genetic characterization of Streptococcus pneumoniae mutants resistant to the des-F(6) quinolone BMS-284756.
Antimicrobial agents and chemotherapy - 1 Oct 2001
Hartman-Neumann S, DenBleyker K, Pelosi L A, Lawrence L E, Barrett J F, Dougherty T J
Abstract excerpt
Existing quinolones are known to target the type II topoisomerases in bacteria. In order to determine which of these targets are of key importance in Streptococcus pneumoniae treated with BMS-284756 (T-3811ME), a novel des-F(6) quinolone, resistant mutants were selected in several steps of increasing resistance by plating pneumococci on a series of blood agar plates containing serial twofold-increasing...
Topics
- Anti-Infective Agents
- DNA Gyrase
- DNA Topoisomerase IV
- Drug Resistance, Microbial
- Fluoroquinolones
- Indoles
- Microbial Sensitivity Tests
- Mutation
- Polymerase Chain Reaction
- Quinolones