Article
Genomic characterization of ciprofloxacin resistance in a laboratory-derived mutant and a clinical isolate of Streptococcus pneumoniae.
Antimicrobial agents and chemotherapy - 1 Oct 2013
Lupien Andréanne, Billal Dewan S, Fani Fereshteh, Soualhine Hafid, Zhanel George G, Leprohon Philippe, Ouellette Marc
Abstract excerpt
The broad-spectrum fluoroquinolone ciprofloxacin is a bactericidal antibiotic targeting DNA topoisomerase IV and DNA gyrase encoded by the parC and gyrA genes. Resistance to ciprofloxacin in Streptococcus pneumoniae mainly occurs through the acquisition of mutations in the quinolone resistance-determining region (QRDR) of the ParC and GyrA targets. A role in low-level ciprofloxacin resistance has also been...
Topics
- Anti-Bacterial Agents
- Ciprofloxacin
- Genome, Bacterial
- Microbial Sensitivity Tests
- Mutation
- Reactive Oxygen Species
- Reverse Transcriptase Polymerase Chain Reaction
- Streptococcus pneumoniae