Resistance to Multiple Fluoroquinolones in a Clinical Isolate of Streptococcus pyogenes : Identification of gyrA and parC and Specification of Point Mutations Associated with Resistance

Abstract excerpt

A strain of Streptococcus pyogenes resistant to multiple fluoroquinolones was isolated from the blood of an immunocompromised patient. Resistance to fluoroquinolones in S. pyogenes has not been previously studied. Compared to 10 sensitive strains of S. pyogenes, the fluoroquinolone-resistant clinical isolate of S. pyogenes presented point mutations in gyrA, predicting that serine-81 was changed to phenylalanine...

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