Article
Molecular characterisation of the quinolone resistance-determining regions (QRDR) including gyrA, gyrB, parC and parE genes in Streptococcus pneumoniae.
British journal of biomedical science - 1 Jan 2012
Kakinuma Y, Maeda Y, Mason C, Goldsmith C E, Coulter W A, Matsuda M, Dooley J S G, Lowery C J, Moore J E
Abstract excerpt
Streptococcus pneumoniae is the leading cause of community-acquired pneumonia (CAP). Currently, empirical treatment with quinolones is being used due to the emergence of beta-lactam and macrolide resistance in S. pneumonaie. Although the prevalence of quinolone-resistant S. pneumoniae remains low, increasing numbers of resistant isolates are being seen. Genetic mechanisms leading to fluoroquinolone resistance in...
Topics
- Adult
- Cell Survival
- Child
- DNA Gyrase
- DNA Topoisomerase IV
- Drug Resistance, Bacterial
- Humans
- Microbial Sensitivity Tests
- Mutation
- Quinolones
- Streptococcus pneumoniae