Article
Nonmolecular test for detection of low-level resistance to fluoroquinolones in Streptococcus pneumoniae.
Antimicrobial agents and chemotherapy - 1 Feb 2006
Varon Emmanuelle, Houssaye Serge, Grondin Sophie, Gutmann Laurent
Abstract excerpt
With respect to pneumococci, there is a need to detect first-step mutants with reduced fluoroquinolone (FQ) susceptibility from which second-step, resistant mutants are likely to be selected in the presence of antipneumococcal FQs. Here, we describe an interpretative disk diffusion test, of which three options are presented, that allows the distinction between first- and second-step mutants. Using five FQ disks...
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