Article
IgH gene rearrangements on the unexpressed allele in rabbit B cells.
Journal of immunology (Baltimore, Md. : 1950) - 15 May 1997
Tunyaplin C, Knight K L
Abstract excerpt
VDJ genes are assembled in two sequential DNA recombination steps, rearrangement of D and J(H) gene segments followed by rearrangement of a V(H) gene segment. In mouse and human, VDJ gene rearrangements occur in a regulated step in which D rearranges to J(H) on both alleles before V(H) rearranges to DJ. To determine how VDJ gene rearrangements are regulated in the rabbit, we studied the IgH gene rearrangements in...
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