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Antigen-Induced Somatic Diversification of Rabbit IgH Genes: Gene Conversion and Point Mutation

1 Jun 1999

Abstract excerpt

During T cell-dependent immune responses in mouse and human, Ig genes diversify by somatic hypermutation within germinal centers. Rabbits, in addition to using somatic hypermutation to diversify their IgH genes, use a somatic gene conversion-like mechanism, which involves homologous recombination between upstream VH gene segments and the rearranged VDJ genes. Somatic gene conversion and somatic hypermutation...

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Identifiers

PMID: 10352277
DOI: 10.4049/jimmunol.162.11.6602

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