Novel immunoglobulin heavy chains are produced from DJH gene segment rearrangements in lymphoid cells.

doi:10.1038/312418a0

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Article

Novel immunoglobulin heavy chains are produced from DJH gene segment rearrangements in lymphoid cells.

Nature - 1 Jan 2000

Reth M G, Alt F W

Abstract excerpt

It has been found that most immunoglobulin heavy(H)-chain gene diversity (D) segments carry their own 5' transcriptional promoter element. Transcription of rearrangements which use heavy-chain D and joining (J) segments in B-lymphoid cells ultimately leads to the production of a Dmu messenger RNA...

Topics

Abelson murine leukemia virus
Alleles
Amino Acid Sequence
Animals
Antigens, Surface
Base Sequence
Bone Marrow
CD3 Complex
Cell Line
Cell Transformation, Neoplastic
Cloning, Molecular
DNA Restriction Enzymes
Genes
Immunoglobulin Heavy Chains
Immunoglobulin mu-Chains
Lymphocytes
Mice
Mice, Inbred BALB C

Source

Open in PubMed

Identifiers

PMID: 6095102
DOI: 10.1038/312418a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-6095102-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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