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Article

Novel immunoglobulin heavy chains are produced from DJH gene segment rearrangements in lymphoid cells.

Nature - 1 Jan 2000

Reth M G, Alt F W

Abstract excerpt

It has been found that most immunoglobulin heavy(H)-chain gene diversity (D) segments carry their own 5' transcriptional promoter element. Transcription of rearrangements which use heavy-chain D and joining (J) segments in B-lymphoid cells ultimately leads to the production of a Dmu messenger RNA which contains the DJH segments linked to the mu heavy-chain constant region. If the D is joined to the JH segment in...

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PMID: 6095102
DOI: 10.1038/312418a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Novel immunoglobulin heavy chains are produced from DJH gene segment rearrangements in lymphoid cells.PMID 6095102Read ↗

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Persistent expression of an unproductive immunoglobulin heavy chain allele with DH-JH-gamma configuration in peripheral tissues.Semantic proximity Read ↗

Incomplete DJH rearrangements of the IgH gene are frequent in multiple myeloma patients: immunobiological characteristics and clinical implications.Semantic proximity Read ↗

Elements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination.Semantic proximity Read ↗

Somatic variation precedes extensive diversification of germline sequences and combinatorial joining in the evolution of immunoglobulin heavy chain diversity.Semantic proximity Read ↗

Extensive allelic sequence variation in the J region of the human immunoglobulin heavy chain gene locus.Semantic proximity Read ↗

A biological consequence of variation in the site of D-JH gene rearrangement.Semantic proximity Read ↗

Analysis of direct and inverted DJH rearrangements in a human Ig heavy chain transgenic minilocus.Semantic proximity Read ↗

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