Article
HPRT mutant T-cell lines from multiple sclerosis patients recognize myelin proteolipid protein peptides.
Journal of neuroimmunology - 1 May 1997
Trotter J L, Damico C A, Cross A H, Pelfrey C M, Karr R W, Fu X T, McFarland H F
Abstract excerpt
Mutation of the hypoxanthine-guanine phosphoribosyl transferase (HPRT) gene in a T-cell is believed to be an indication that the T-cell has been activated and has proliferated in vivo. HPRT mutant T-cell lines were generated from peripheral blood mononuclear cells from patients with MS and control subjects. More lines were isolated from the MS patients than from the control subjects. Using stringent criteria for...
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