T cells responsive to myelin basic protein in patients with multiple sclerosis.

doi:10.1126/science.1689076

Back to search

Article

T cells responsive to myelin basic protein in patients with multiple sclerosis.

Science (New York, N.Y.) - 9 Feb 1990

Allegretta M, Nicklas J A, Sriram S, Albertini R J

Abstract excerpt

Gene mutation in vivo in human T lymphocytes appears to occur preferentially in dividing cells. Individuals with multiple sclerosis (MS) are assumed to have one or more populations of diving T cells that are being stimulated by autoantigens. Mutant T cell clones from MS patients were isolated and...

Topics

Adult
Autoantigens
Cell Division
Clone Cells
Female
Humans
Hypoxanthine Phosphoribosyltransferase
Male
Middle Aged
Multiple Sclerosis
Mutation
Myelin Basic Protein
T-Lymphocytes
Thioguanine
X Chromosome

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.