Article
Binding of myelin basic protein peptides to human histocompatibility leukocyte antigen class II molecules and their recognition by T cells from multiple sclerosis patients.
The Journal of clinical investigation - 1 Feb 1993
Valli A, Sette A, Kappos L, Oseroff C, Sidney J, Miescher G, Hochberger M, Albert E D, Adorini L
Abstract excerpt
Multiple sclerosis (MS) is an autoimmune disease in which myelin proteins have been implicated as autoantigens recognized by pathogenic autoreactive T cells. To study the relationship between human myelin basic protein (hMBP) and HLA alleles associated to MS susceptibility, such as DRB1*1501, the...
Topics
- Adult
- Aged
- Alleles
- Amino Acid Sequence
- Cell Line
- Female
- HLA-DQ Antigens
- HLA-DR Antigens
- Histocompatibility Antigens Class II
- Humans
- Immunodominant Epitopes
- Male
- Middle Aged
- Molecular Sequence Data