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Article

Evidence against chronic antigen-specific T lymphocyte activation in myasthenia gravis.

Journal of neuroscience research - 15 Aug 1996

Infante A J, Infante P D, Jackson C E, Barohn R J, Tami J, Iturriaga E, Talib S, Kraig E, Clarkin K Z, Krolick K A

Abstract excerpt

Myasthenia gravis (MG) is an antigen-specific autoimmune disease caused by antibodies against acetylcholine receptors (AChR) at the post-synaptic membrane of the neuromuscular junction. Clinical and immunological data imply the involvement of AChR-specific T lymphocytes as helper cells for autoantibody production. Direct data to support this hypothesis, however, remain sparse. In the present study, a large...

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Identifiers

PMID: 8872911
DOI: 10.1002/(SICI)1097-4547(19960815)45:4<492::AID-JNR20>3.0.CO;2-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Evidence against chronic antigen-specific T lymphocyte activation in myasthenia gravis.PMID 8872911Read ↗

Autoreactive T Cells from Patients with Myasthenia Gravis Are Characterized by Elevated IL-17, IFN-γ, and GM-CSF and Diminished IL-10 Production.Semantic proximity Read ↗

T-cell recognition of acetylcholine receptor provides a reliable means for monitoring autoimmunity to acetylcholine receptor in antibody-negative myasthenia gravis patients.Semantic proximity Read ↗

Clonal heterogeneity of thymic B cells from early-onset myasthenia gravis patients with antibodies against the acetylcholine receptor.Semantic proximity Read ↗

A pathogenetic role for the thymoma in myasthenia gravis. Autosensitization of IL-4- producing T cell clones recognizing extracellular acetylcholine receptor epitopes presented by minority class II isotypes.Semantic proximity Read ↗

Somatic hypermutation and selection of B cells in thymic germinal centers responding to acetylcholine receptor in myasthenia gravis.Semantic proximity Read ↗

Acetylcholine receptor-reactive T lymphocytes from healthy subjects and myasthenia gravis patients.Semantic proximity Read ↗

Thymus-derived B cell clones persist in the circulation after thymectomy in myasthenia gravisSemantic proximity Read ↗

Determinant spreading and immune responses to acetylcholine receptors in myasthenia gravisSemantic proximity Read ↗

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