Article
Frequency of MBP and MBP peptide-reactive T cells in the HPRT mutant T-cell population of MS patients.
Neurology - 1 May 1996
Lodge P A, Johnson C, Sriram S
Abstract excerpt
Somatic mutation as an index of in vivo T-cell amplification is a powerful tool to analyze the specificity and size of the autoreactive T-cell repertoire. Using this strategy, we determined the precursor frequency of T cells reactive to myelin basic protein (MBP) and overlapping MBP peptides span...
Topics
- Adolescent
- Adult
- Amino Acid Sequence
- Cells, Cultured
- Female
- HLA-DR Antigens
- Histocompatibility Testing
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Male
- Middle Aged
- Molecular Sequence Data
- Multiple Sclerosis
- Mutation
- Myelin Basic Protein
- Nervous System Diseases
- Peptide Fragments
- Reference Values