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Article

Frequency of MBP and MBP peptide-reactive T cells in the HPRT mutant T-cell population of MS patients.

Neurology - 1 May 1996

Lodge P A, Johnson C, Sriram S

Abstract excerpt

Somatic mutation as an index of in vivo T-cell amplification is a powerful tool to analyze the specificity and size of the autoreactive T-cell repertoire. Using this strategy, we determined the precursor frequency of T cells reactive to myelin basic protein (MBP) and overlapping MBP peptides spanning regions p84-168 in patients with MS and controls in the HPRT mutant T-cell population. Among 19 MS patients, nine...

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Identifiers

PMID: 8628491
DOI: 10.1212/wnl.46.5.1410

Genes

MBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Frequency of MBP and MBP peptide-reactive T cells in the HPRT mutant T-cell population of MS patients.PMID 8628491Read ↗

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