Article
Human T lymphocytes recognize a peptide of single point-mutated, oncogenic ras proteins.
The Journal of experimental medicine - 1 Jan 1991
Jung S, Schluesener H J
Abstract excerpt
P21ras proteins are thought to play an important role in cell proliferation and differentiation. Single nucleotide mutations in the encoding cellular proto-oncogenes often result in p21ras proteins with transforming activity. Such activated ras oncogenes have been demonstrated in a variety of human malignancies and also in preneoplastic changes. Using a synthetic peptide corresponding to amino acids 5-16 of...
Topics
- Amino Acid Sequence
- CD4-Positive T-Lymphocytes
- HLA-D Antigens
- Humans
- Molecular Sequence Data
- Mutation
- Oncogene Protein p21(ras)
- Peptide Fragments
- T-Lymphocytes