Article
Characterization of in vivo mutated T cell clones from patients with systemic lupus erythematosus.
Clinical immunology and immunopathology - 1 Feb 1995
Theocharis S, Sfikakis P P, Lipnick R N, Klipple G L, Steinberg A D, Tsokos G C
Abstract excerpt
Patients with systemic lupus erythematosus (SLE) have increased percentages of activated T cells and increased numbers of cells with mutations in their hypoxanthineguanine phosphoribosyltransferase (hprt) gene, as judged by growth in the presence of 6-thioguanine. To study the relevance of these mutant T cells to disease pathogenesis, we have assessed the phenotype and functional capabilities of such cells from...
Topics
- Adolescent
- Adult
- Aged
- Antibodies, Antinuclear
- Antigen-Presenting Cells
- Autoantigens
- Clone Cells
- DNA, Single-Stranded
- Female
- Humans
- Hypoxanthine Phosphoribosyltransferase