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Article

Characterization of in vivo mutated T cell clones from patients with systemic lupus erythematosus.

Clinical immunology and immunopathology - 1 Feb 1995

Theocharis S, Sfikakis P P, Lipnick R N, Klipple G L, Steinberg A D, Tsokos G C

Abstract excerpt

Patients with systemic lupus erythematosus (SLE) have increased percentages of activated T cells and increased numbers of cells with mutations in their hypoxanthineguanine phosphoribosyltransferase (hprt) gene, as judged by growth in the presence of 6-thioguanine. To study the relevance of these mutant T cells to disease pathogenesis, we have assessed the phenotype and functional capabilities of such cells from...

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Identifiers

PMID: 7828367
DOI: 10.1006/clin.1995.1020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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