A test statistic to detect errors in sib-pair relationships.

Abstract excerpt

Several authors have proposed algorithms to detect Mendelian errors in human genetic linkage data. Most currently available methods use likelihood-based methods on multiplex family data to identify typing or pedigree errors. These algorithms cannot be applied in many sib-pair collections, because of lack of parental-genotype information. Nonetheless, misspecifying the relationships between individuals has serious...

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