Article
Log-linear models for gene mapping with affected sib pair data.
Human heredity - 1 Jan 2002
Yang Yang, Ott Jürg
Abstract excerpt
In genome-wide screens of genetic marker loci, non-mendelian inheritance of a marker is taken to indicate its vicinity to a disease locus. Heritable complex traits are thought to be under the influence of multiple possibly interacting susceptibility loci yet the most frequently used methods of linkage and association analysis focus on one susceptibility locus at a time. Here we introduce log-linear models for the...
Topics
- Alleles
- Chromosome Mapping
- Genetic Linkage
- Genetic Markers
- Heterozygote
- Humans
- Likelihood Functions
- Linear Models
- Models, Genetic
- Siblings