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Article

Conformation and surface expression of free HLA-CW1 heavy chains in the absence of beta 2-microglobulin.

Human immunology - 1 Mar 1997

Martayan A, Fiscella M, Setini A, Ciccarelli G, Gambari R, Feriotto G, Beretta A, Siccardi A G, Appella E, Giacomini P

Abstract excerpt

A beta 2-microglobulin (beta 2m)-deficient kidney carcinoma cell line and three monoclonal antibodies to the alpha 1 (L31), alpha 2 (W6/32), and alpha 3 (Q1/28) domain of class I HLA molecules were selected to assess the role of beta 2m in regulating the conformation and surface expression of HLA-C molecules. HLA-A2, -B27, and -CW1 molecules synthesized by beta 2m-deficient cells were compared to heavy chains...

Topics

Carcinoma, Renal Cell
Cell Separation
Detergents
Genotype
HLA-A Antigens
HLA-B Antigens
HLA-C Antigens
Humans
Isoelectric Focusing
Kidney Neoplasms
Octoxynol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polyethylene Glycols

Protein Conformation

Transfection

Tumor Cells, Cultured

beta 2-Microglobulin

Source

Identifiers

PMID: 9127144
DOI: 10.1016/S0198-8859(96)00256-X

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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