Article
Total HLA class I loss in a sarcomatoid renal carcinoma cell line caused by the coexistence of distinct mutations in the two encoding beta2-microglobulin genes.
Cancer immunology, immunotherapy : CII - 1 Mar 2009
Hsieh Chin-Hsuan, Hsu Ya-Jan, Chang Chien-Chung, Liu Hsin-Chun, Chuang Kun-Lung, Chuang Cheng-Keng, Pang See-Tong, Hasumi Kenichiro, Ferrone Soldano, Liao Shuen-Kuei
Abstract excerpt
In renal cell carcinoma (RCC), HLA class I downregulation has been found in about 40% of the lesions examined. Since only scanty information is available about the molecular basis of these defects, we have investigated the mechanism(s) underlying HLA class I antigen downregulation or loss in six RCC cell lines. Five of them express HLA class I antigens although at various levels; on the other hand, HLA class I...
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