Article
Expression of HLA class I molecules assembled with structural variants of human beta2-microglobulin.
Immunogenetics - 1 Jan 1997
Trymbulak W P, Zeff R A
Abstract excerpt
Mouse and human beta2-microglobulin (beta2m), which differ by 30% in their primary sequence, give rise to disparate levels of HLA class I heavy chain expression in transfectants of the beta2m-null FO-1 human melanoma cell line, i.e., mouse beta2m directs expression of HLA class I heavy chains tha...
Topics
- Amino Acid Sequence
- Animals
- Cell Line
- Cold Temperature
- Flow Cytometry
- Fluorescent Antibody Technique, Indirect
- Gene Expression Regulation
- Genetic Variation
- Histocompatibility Antigens Class I
- Humans
- Mice
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Recombinant Fusion Proteins
- Sequence Homology, Amino Acid
- Species Specificity
- Transfection
- beta 2-Microglobulin