Altered phenotype of HT29 colonic adenocarcinoma cells following expression of the DCC gene.

doi:10.1038/sj.onc.1202610

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Article

Altered phenotype of HT29 colonic adenocarcinoma cells following expression of the DCC gene.

Oncogene - 22 Apr 1999

Velcich A, Corner G, Palumbo L, Augenlicht L

Abstract excerpt

On 18q, frequently deleted in late stage colorectal cancers, a gene, Deleted in Colon Cancer (DCC), has been identified and postulated to play a role as a tumor suppressor gene. DCC is retained in the majority of mucinous tumors, which produce high levels of mucins, and seems to be preferentially expressed in intestinal goblet cells. To investigate whether DCC is related to mucin expression and can modulate the...

Topics

Adenocarcinoma
Cell Adhesion Molecules
Cell Differentiation
Cell Transformation, Neoplastic
Colonic Neoplasms
DCC Receptor
Genes, DCC
Goblet Cells
HT29 Cells
Humans
Loss of Heterozygosity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mucin-2

Mucins

Phenotype

Receptors, Cell Surface

Recombinant Proteins

Tumor Suppressor Proteins

Source

Open in PubMed

Identifiers

PMID: 10353603
DOI: 10.1038/sj.onc.1202610

Genes

DCC
MUC2

Provenance

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