Article
In vitro analysis of the role of DCC in mucus-secreting intestinal differentiation.
International journal of cancer - 31 May 1999
Fabre M, Martin M, Ulloa F, Real F X
Abstract excerpt
The deleted in colorectal cancer (DCC) gene was initially described as a colon cancer-associated tumor suppressor gene and subsequently proposed to be involved in goblet cell differentiation, but its precise role in normal intestine physiology and in cancer remains to be established. We have analyzed DCC mRNA expression in a panel of human colorectal cancer cell lines with a variety of differentiation phenotypes...
Topics
- Cell Adhesion Molecules
- Cell Differentiation
- Cell Division
- Cell Polarity
- Colorectal Neoplasms
- DCC Receptor
- Fluorescent Antibody Technique, Indirect
- Gene Expression Regulation, Neoplastic
- Genes, Tumor Suppressor
- HT29 Cells
- Humans
- Intestinal Mucosa
- Mucins
- Mucus