Article
Increased frequency of specific locus mutation following human cytomegalovirus infection.
Virology - 31 Mar 1997
Albrecht T, Fons M P, Deng C Z, Boldogh I
Abstract excerpt
The effect of human cytomegalovirus (HCMV) infection on the frequency of mutations at the hypoxanthine-guanine phosphoribosyl transferase (hprt) locus was studied in Chinese hamster lung V79 cells. When V79 cells were infected with HCMV (strain AD169) at multiplicities of 0.1 to 50 plaque forming units (PFU) per cell the presumptive mutation frequency, as determined by the number of 6-thioguanine-resistant (TGr)...
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