Characterization of mutants involving partial exon duplications in the hprt gene of Chinese hamster V79 cells.

doi:10.1007/BF02369910

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Article

Characterization of mutants involving partial exon duplications in the hprt gene of Chinese hamster V79 cells.

Somatic cell and molecular genetics - 1 May 1996

Darè E, Zhang L H, Jenssen D

Abstract excerpt

Sequencing of hprt cDNA revealed that three spontaneous mutants in V79 Chinese hamster cells exhibit tandem duplications of exon(s), i.e., either exons 2 and 3 or exon 7. Sequences of different sizes (4.5-8 Kb) were found to be duplicated and inserted in tandem into the hprt gene. These mutants d...

Topics

Animals
Blotting, Southern
Cell Line
Cricetinae
Cricetulus
DNA, Complementary
Exons
Hypoxanthine Phosphoribosyltransferase
Multigene Family
Mutation
Sequence Analysis, DNA

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