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Transgenic Chinese hamster V79 cell lines which exhibit variable levels of gpt mutagenesis.

Environmental and molecular mutagenesis - 1 Jan 1990

Klein C B, Rossman T G

Abstract excerpt

The Escherichia coli gpt gene coding for xanthine-guanine phosphoribosyl transferase has been stably transfected into HPRT- Chinese hamster V79 cells. Several gpt- cell lines have been established, which retain the sequence(s) even after long-term culture without selection for gpt. Each cell line exhibits a characteristic spontaneous mutation frequency (10(-5) to 10(-2)) in 6-thioguanine (6TG) selection. While...

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PMID: 2197084
DOI: 10.1002/em.2850160102

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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