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Article

Induction of duplication reversion in human fibroblasts, by wild-type and mutated SV40 T antigen, covaries with the ability to induce host DNA synthesis.

Genetics - 1 Aug 1997

Shammas M A, Xia S J, Shmookler Reis R J

Abstract excerpt

Intrachromosomal homologous recombination, manifest as reversion of a 14-kbp duplication in the hypoxanthine phosphoribosyl transferase (HPRT) gene, is elevated in human cells either stably transformed or transiently transfected by the SV40 (simian virus 40) large T antigen gene. Following introduction of wild-type SV40, or any of several T-antigen point mutations in a constant SV40 background, we observed a...

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Identifiers

PMID: 9258684
DOI: 10.1093/genetics/146.4.1417
PMCID: PMC1208085

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Source receipt: pubmed, retrieved 7 Sept 2026.

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