Article
Forward mutations and DNA-protein crosslinks induced by ammonium metavanadate in cultured mammalian cells.
Mutation research - 1 Sept 1992
Cohen M D, Klein C B, Costa M
Abstract excerpt
Ammonium metavanadate yielded a dose-dependent increase in mutation frequency at the V79 hprt locus following a 24-h exposure period in serum-free F12 medium. Vanadate also increased the mutation frequency of V79 cells by exposure of cells in salts-glucose medium, but these effects were not as striking, or as dose-dependent as they were in serum-free F12 medium. Ammonium metavanadate enhanced the mutation...
Topics
- Animals
- CHO Cells
- Cell Line
- Chromates
- Cricetinae
- Cross-Linking Reagents
- DNA
- DNA-Binding Proteins
- Dose-Response Relationship, Drug
- Humans
- Mutagenicity Tests
- Mutation