Article
No association of the -48CT polymorphism of the presenilin 1 gene with Alzheimer disease in a late-onset sporadic population.
Journal of neural transmission (Vienna, Austria : 1996) - 1 Jul 2002
Araria-Goumidi L, Huguet J B, Lambert J C, Frigard B, Cottel D, Amouyel P, Chartier-Harlin M C
Abstract excerpt
Recently, a polymorphism located in the promoter of the presenilin 1 gene was associated with early-onset Alzheimer disease (EOAD). To determine if this polymorphism is also a risk factor for late-onset Alzheimer's disease (LOAD), we analysed its potential impact in a French population of LOAD patients only. Genotype and allelic distributions of the -48CT polymorphism were similar for controls and AD patients....
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