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Article

Megakaryocytic differentiation induced by constitutive activation of mitogen-activated protein kinase kinase.

Molecular and cellular biology - 1 Apr 1997

Whalen A M, Galasinski S C, Shapiro P S, Nahreini T S, Ahn N G

Abstract excerpt

The K562 erythroleukemia cell line was used to study the molecular mechanisms regulating lineage commitment of hematopoietic stem cells. Phorbol esters, which initiate megakaryocyte differentiation in this cell line, caused a rapid increase in extracellular-signal-regulated kinase (ERK), which remained elevated for 2 h and returned to near-basal levels by 24 h. In the absence of extracellular stimuli, ERK could...

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Identifiers

PMID: 9121442
DOI: 10.1128/MCB.17.4.1947
PMCID: PMC232041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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