Article
Megakaryocytic differentiation induced by constitutive activation of mitogen-activated protein kinase kinase.
Molecular and cellular biology - 1 Apr 1997
Whalen A M, Galasinski S C, Shapiro P S, Nahreini T S, Ahn N G
Abstract excerpt
The K562 erythroleukemia cell line was used to study the molecular mechanisms regulating lineage commitment of hematopoietic stem cells. Phorbol esters, which initiate megakaryocyte differentiation in this cell line, caused a rapid increase in extracellular-signal-regulated kinase (ERK), which re...
Topics
- Base Sequence
- Cell Differentiation
- Cell Division
- DNA Primers
- Enzyme Activation
- Erythropoiesis
- Gene Expression
- Globins
- Humans
- Leukemia, Erythroblastic, Acute
- Megakaryocytes
- Mitogen-Activated Protein Kinase Kinases
- Mutation
- Platelet Glycoprotein GPIIb-IIIa Complex
- Protein Kinases
- Signal Transduction
- Tetradecanoylphorbol Acetate
- Tumor Cells, Cultured