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Article

Role of the tyrosine phosphatase SHP-1 in K562 cell differentiation.

Leukemia - 1 Sept 2001

Bruecher-Encke B, Griffin J D, Neel B G, Lorenz U

Abstract excerpt

The erythro-megakaryoblastic leukemia cell line K562 undergoes erythroid or myeloid differentiation in response to treatment with various inducing agents. We observed that expression of the SH2-containing protein tyrosine phosphatase SHP-1 was induced upon exposure of K562 cells to differentiating agents. Under the same conditions, expression of SHP-2, a close relative of SHP-1, and the more distantly related...

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PMID: 11516103
DOI: 10.1038/sj.leu.2402214

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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