Article
The genomic and proteomic blueprint of mouse megakaryocytes derived from embryonic stem cells.
Journal of thrombosis and haemostasis : JTH - 1 May 2012
Merico V, Zuccotti M, Carpi D, Baev D, Mulas F, Sacchi L, Bellazzi R, Pastorelli R, Redi C A, Moratti R, Garagna S, Balduini A
Abstract excerpt
BACKGROUND: Platelets are specialized cells, produced by megakaryocytes (MKs) in the bone marrow, which represent the first defense against hemorrhage. There are many diseases where platelet production or function is impaired, with severe consequences for patients. Therefore, new insights into the process of MK differentiation and platelet formation would have a major impact on both basic and clinical research....
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